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Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4 CD25 high T cells with susceptibility in Kenyans.

Abstract:

BACKGROUND: Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection in the field have been limited. The objective of this study was to investigate cell-mediated immune correlates of protection in natural malaria. Memory T cells reactive against thrombospondin-related adhesive protein (TRAP) and circumsporozoit...

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Publication status:
Published

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Authors


Todryk, SM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Plebanski, M More by this author
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Journal:
PloS one
Volume:
3
Issue:
4
Pages:
e2027
Publication date:
2008
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:4e1eba1c-57c4-4254-a7a7-b945acffc5f2
Source identifiers:
34214
Local pid:
pubs:34214

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