Journal article
Genomic and epidemiological monitoring of yellow fever virus transmission potential
- Abstract:
- The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 2.2MB, Terms of use)
-
- Publisher copy:
- 10.1126/science.aat7115
Authors
+ National Institutes of Health
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- Funding agency for:
- Kraemer, MUG
- Grant:
- R01LM011965
+ National Institute of Child Health and Human Development
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- Funding agency for:
- Kraemer, MUG
- Grant:
- R01LM011965
+ Eidgenössische Technische Hochschule Zürich
More from this funder
- Funding agency for:
- Kraemer, MUG
- Grant:
- R01LM011965
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science More from this journal
- Volume:
- 361
- Issue:
- 6405
- Pages:
- 894-899
- Publication date:
- 2018-08-31
- Acceptance date:
- 2018-07-20
- DOI:
- EISSN:
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1095-9203
- ISSN:
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0036-8075
- Pmid:
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30139911
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:911055
- UUID:
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uuid:4d6b67ea-d540-450f-a8c0-a6c4f2e65ace
- Local pid:
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pubs:911055
- Source identifiers:
-
911055
- Deposit date:
-
2018-09-26
- ARK identifier:
Terms of use
- Copyright holder:
- Faria et al
- Copyright date:
- 2018
- Notes:
- 2017 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: https://doi.org/10.1126/science.aat7115
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