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3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial

Abstract:
Background 6 months of oxaliplatin-containing chemotherapy is usually given as adjuvant treatment for stage 3 colorectal cancer. We investigated whether 3 months of oxaliplatin-containing chemotherapy would be non-inferior to the usual 6 months of treatment.

Methods The SCOT study was an international, randomised, phase 3, non-inferiority trial done at 244 centres. Patients aged 18 years or older with high-risk stage II and stage III colorectal can... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S1470-2045(18)30093-7

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author


Publisher:
Elsevier
Journal:
Lancet Oncology More from this journal
Volume:
19
Issue:
4
Pages:
562-578
Publication date:
2018-03-28
Acceptance date:
2018-01-25
DOI:
EISSN:
1474-5488
ISSN:
1470-2045
Pmid:
29611518


Language:
English
Pubs id:
pubs:833619
UUID:
uuid:4d403693-354c-4441-80b0-0109a601be79
Local pid:
pubs:833619
Source identifiers:
833619
Deposit date:
2019-03-11

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