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Journal article

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

Abstract:

The extreme polymorphism in the human leukocyte antigen (HLA) class I region of the human genome is suggested to provide an advantage in pathogen defence mediated by CD8+ T cells. HLA class I molecules present pathogen-derived peptides on the surface of infected cells for recognition by CD8+ T cells. However, the relative contributions of HLA-A and -B alleles have not been evaluated. We performed a comprehensive analysis of the class I restricted CD8+ T-cell responses against human immunodefi...

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Publication status:
Published

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Publisher copy:
10.1038/nature03113

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Journal:
Nature
Volume:
432
Issue:
7018
Pages:
769-775
Publication date:
2004-12-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:4d1a7fb5-09f3-4e16-ac51-315e1dd44b6e
Source identifiers:
21121
Local pid:
pubs:21121

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