- Abstract:
-
The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and inflammatory pain models in the rat. The ED50 for the anti-nociceptive (increasing mechanical withdrawal threshold) effect was 0.1 mg/kg-1 i.p., and for anti-hypersensitivity and anti-inflammatory activity was 5 g/kg-1 i.p. (in the carrageenan model). The selective CB1 antagonist, AM281 (0.5 microg/kg-1 i.p.) reversed effects of HU210 (10 and 30 microg/kg-1 i.p.) in both nociceptive and inflammatory models of hyperse...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0304-3959(01)00454-7
-
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- Journal:
- Pain
- Volume:
- 96
- Issue:
- 3
- Pages:
- 253-260
- Publication date:
- 2002-04-05
- DOI:
- EISSN:
-
1872-6623
- ISSN:
-
0304-3959
- URN:
-
uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
- Source identifiers:
-
32095
- Local pid:
- pubs:32095
- Copyright date:
- 2002
Journal article
CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.
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