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Journal article

CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.

Abstract:

The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and inflammatory pain models in the rat. The ED50 for the anti-nociceptive (increasing mechanical withdrawal threshold) effect was 0.1 mg/kg-1 i.p., and for anti-hypersensitivity and anti-inflammatory activity was 5 g/kg-1 i.p. (in the carrageenan model). The selective CB1 antagonist, AM281 (0.5 microg/kg-1 i.p.) reversed effects of HU210 (10 and 30 microg/kg-1 i.p.) in both nociceptive and inflammatory models of hyperse...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Pain
Volume:
96
Issue:
3
Pages:
253-260
Publication date:
2002-04-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
URN:
uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
Source identifiers:
32095
Local pid:
pubs:32095

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