Journal article
Negative Ions Enhance Survival of Membrane Protein Complexes
- Abstract:
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Membrane protein complexes are commonly introduced to the mass spectrometer solubilized in detergent micelles. The collisional activation used to remove the detergent, however, often causes protein unfolding and dissociation. As in the case for soluble proteins, electrospray in the positive ion mode is most commonly used for the study of membrane proteins. Here we show several distinct advantages of employing the negative ion mode. Negative polarity can yield lower average charge states for m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 206.6KB)
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(Version of record, pdf, 1.5MB)
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- Publisher copy:
- 10.1007/s13361-016-1381-5
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Authors
Bibliographic Details
- Publisher:
- Springer Verlag Publisher's website
- Journal:
- Journal of the American Society for Mass Spectrometry Journal website
- Issue:
- 6
- Publication date:
- 2016-04-22
- Acceptance date:
- 2016-03-08
- DOI:
- EISSN:
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1879-1123
- ISSN:
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1044-0305
- Source identifiers:
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624863
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:624863
- UUID:
-
uuid:4ce3ed7b-0afe-4a93-9b3c-e0aeda76d668
- Local pid:
- pubs:624863
- Deposit date:
- 2016-08-31
Terms of use
- Copyright holder:
- Liko et al
- Copyright date:
- 2016
- Notes:
- © The Author(s), 2016. This article is published with open access at Springerlink.com.
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