Proteolytic modulation of tumor microenvironment signals during cancer progression

Journal article

Abstract:: Under normal conditions, the cellular microenvironment is optimized for the proper functioning of the tissues and organs. Cells recognize and communicate with the surrounding cells and extracellular matrix to maintain homeostasis. When cancer arises, the cellular microenvironment is modified to optimize its malignant growth, evading the host immune system and finding ways to invade and metastasize to other organs. One means is a proteolytic modification of the microenvironment and the signaling molecules. It is now well accepted that cancer progression relies on not only the performance of cancer cells but also the surrounding microenvironment. This mini-review discusses the current understanding of the proteolytic modification of the microenvironment signals during cancer progression.

Files:: Itoh_2022_Proteolytic_modulation_of.pdf

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Language:: English
Keywords:: matrikine

ECM

membrane protein shedding

proteinases

FFR

TME

invasion

soluble factors
Pubs id:: 1277539
Local pid:: pubs:1277539
Deposit date:: 2022-09-06

Copyright holder:: Yoshifumi Itoh
Rights statement:: © 2022 Itoh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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