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Journal article

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment.

Abstract:

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and the second most common frequent leukemia of childhood. Patients may present with lymphopenia or pancytopenia at diagnosis. We investigated the mechanisms by which AML causes pancytopenia and suppresses patients' immune response. This study identified for the first time that AML blasts alter the immune microenvironment through enhanced arginine metabolism. Arginase II is expressed and released from AML blasts and is p...

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Publication status:
Published

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Journal:
Blood
Volume:
122
Issue:
5
Pages:
749-758
Publication date:
2013-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:4cd5c549-f15c-4cbc-8a02-8784ee501101
Source identifiers:
401461
Local pid:
pubs:401461

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