- Abstract:
-
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and the second most common frequent leukemia of childhood. Patients may present with lymphopenia or pancytopenia at diagnosis. We investigated the mechanisms by which AML causes pancytopenia and suppresses patients' immune response. This study identified for the first time that AML blasts alter the immune microenvironment through enhanced arginine metabolism. Arginase II is expressed and released from AML blasts and is p...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2013-01-480129
-
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- Journal:
- Blood
- Volume:
- 122
- Issue:
- 5
- Pages:
- 749-758
- Publication date:
- 2013-08-05
- DOI:
- EISSN:
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1528-0020
- ISSN:
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0006-4971
- URN:
-
uuid:4cd5c549-f15c-4cbc-8a02-8784ee501101
- Source identifiers:
-
401461
- Local pid:
- pubs:401461
- Copyright date:
- 2013
Journal article
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment.
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