Journal article
Identification and structural characterization of a mutant KRAS‐G12V specific TCR restricted by HLA‐A3
- Abstract:
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Mutations in KRAS are some of the most common across multiple cancer types and are thus attractive targets for therapy. Recent studies demonstrated that mutant KRAS generates immunogenic neoantigens that are targetable by adoptive T‐cell therapy in metastatic diseases. To expand mutant KRAS‐specific immunotherapies, it is critical to identify additional HLA‐I allotypes that can present KRAS neoantigens and their cognate T‐cell receptors (TCR). Here, we identified a murine TCR specific to a KR...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.1MB, Terms of use)
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- Publisher copy:
- 10.1002/eji.202451079
Authors
Funding
+ National Institute of Allergy and Infectious Diseases
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Funder identifier:
https://ror.org/043z4tv69
Bibliographic Details
- Publisher:
- Wiley
- Journal:
- European Journal of Immunology More from this journal
- Article number:
- 2451079
- Publication date:
- 2024-07-18
- Acceptance date:
- 2024-06-21
- DOI:
- EISSN:
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1521-4141
- ISSN:
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0014-2980 and 1521-4141
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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2017473
- Local pid:
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pubs:2017473
- Source identifiers:
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2121929
- Deposit date:
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2024-07-19
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