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Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9.

Abstract:

The role of proteases in the tumor cell invasion process is multifaceted. Members of the matrix metalloproteinase (MMP) family have been implicated in primary and metastatic tumor growth, angiogenesis, and degradation of extracellular matrix (ECM) components. Differentiating between the up-regulation of MMP production and the presence of activated MMPs can be difficult but may well dictate which MMPs are critical to invasion. Because the hydrolysis of collagens is one of the committed steps i...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m211330200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of biological chemistry
Volume:
278
Issue:
20
Pages:
18140-18145
Publication date:
2003-05-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
227106
Language:
English
Keywords:
Pubs id:
pubs:227106
UUID:
uuid:4cb7bc39-8cbf-41ae-b22d-512c2309112e
Local pid:
pubs:227106
Deposit date:
2012-12-19

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