Journal article

The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture.

Abstract:: We report structural models for the most abundant oligomers populated by the polydisperse molecular chaperone αB-crystallin. Subunit connectivity is determined by using restraints obtained from nuclear magnetic resonance spectroscopy and mass spectrometry measurements, enabling the construction of various oligomeric models. These candidate structures are filtered according to their correspondence with ion-mobility spectrometry data and cross-validated by using electron microscopy. The ensuing best-fit structures reveal the polyhedral architecture of αB-crystallin oligomers, and provide a rationale for their polydispersity and facile interconversion.

Publication status:: Published

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APA Style

Baldwin, A., Lioe, H., Hilton, G., Baker, L., Rubinstein, J., Kay, L., & Benesch, J. (2011). The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture. Structure (London, England : 1993), 19(12), 1855–1863.

MLA Style

Baldwin, A., et al. “The Polydispersity of ΑB-Crystallin Is Rationalized by an Interconverting Polyhedral Architecture.” Structure (London, England : 1993), vol. 19, no. 12, 2011, pp. 1855–63.

Chicago Style

Baldwin, A, H Lioe, G Hilton, L Baker, J Rubinstein, L Kay, and J Benesch. 2011. “The Polydispersity of ΑB-Crystallin Is Rationalized by an Interconverting Polyhedral Architecture.” Structure (London, England : 1993) 19 (12): 1855–63.
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Publisher copy:: 10.1016/j.str.2011.09.015

Authors

+ Baldwin, A More by this author

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+ Lioe, H More by this author

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+ Hilton, G More by this author

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+ Baker, L More by this author

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+ Rubinstein, J More by this author

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Journal:: Structure (London, England : 1993) More from this journal
Volume:: 19
Issue:: 12
Pages:: 1855-1863
Publication date:: 2011-12-01
DOI:: 10.1016/j.str.2011.09.015
EISSN:: 1878-4186
ISSN:: 0969-2126

Language:: English
Keywords:: Models, Molecular

alpha-Crystallin B Chain

Mass Spectrometry

Protein Structure, Quaternary

Magnetic Resonance Spectroscopy
Pubs id:: pubs:221302
UUID:: uuid:4cacd9f1-918a-4d6d-a535-94b567581262
Local pid:: pubs:221302
Source identifiers:: 221302
Deposit date:: 2012-12-19

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Copyright date:: 2011

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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