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The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture.

Abstract:

We report structural models for the most abundant oligomers populated by the polydisperse molecular chaperone αB-crystallin. Subunit connectivity is determined by using restraints obtained from nuclear magnetic resonance spectroscopy and mass spectrometry measurements, enabling the construction of various oligomeric models. These candidate structures are filtered according to their correspondence with ion-mobility spectrometry data and cross-validated by using electron microscopy. The ensuing...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2011.09.015

Authors


Journal:
Structure (London, England : 1993) More from this journal
Volume:
19
Issue:
12
Pages:
1855-1863
Publication date:
2011-12-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
Keywords:
Pubs id:
pubs:221302
UUID:
uuid:4cacd9f1-918a-4d6d-a535-94b567581262
Local pid:
pubs:221302
Source identifiers:
221302
Deposit date:
2012-12-19

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