The limiting speed of the bacterial flagellar motor

Journal article

Recent experiments on the bacterial flagellar motor have shown that the structure of this nanomachine, which drives locomotion in a wide range of bacterial species, is more dynamic than previously believed. Specifically, the number of active torque-generating complexes (stators) was shown to vary across applied loads. This finding brings under scrutiny the experimental evidence reporting that limiting (zero-torque) speed is independent of the number of active stators. Here, we propose that, contrary to previous assumptions, the maximum speed of the motor increases as additional stators are recruited. This result arises from our assumption that stators disengage from the motor for a significant portion of their mechanochemical cycles at low loads. We show that this assumption is consistent with current experimental evidence and consolidate our predictions with arguments that a processive motor must have a high duty ratio at high loads.

Authors: Berry, R; Nirody, J; Oster, G

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Biophysical Society
• Journal: Biophysical Journal
• Volume: 111
• Issue: 3
• Pages: 557–564
• Publication date: 2016-08-01
• Acceptance date: 2016-05-07
• DOI: 10.1016/j.bpj.2016.07.003
• ISSN: 1542-0086