Electrospray‐based sample preparation for high‐resolution protein structure elucidation by cryo‐EM

Journal article

Understanding protein structures at the molecular level is of paramount importance in contemporary biomedicine.1 The correlation between variations in protein structures and their biological functions is vital to life processes and intricately linked to the emergence of numerous diseases.2 Revealing the three-dimensional structures of proteins can assist the fundamental research for biology as well as for design of precision therapeutics, a field known as ‘structure-based therapeutics’.3 This...

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Authors: Fan, J; Yang, Z; Liang, L; Wang, J; Wang, H

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley
• Journal: Clinical and Translational Medicine
• Volume: 15
• Issue: 8
• Pages: e70405-e70405
• Publication date: 2025-08-01
• DOI: 10.1002/ctm2.70405
• EISSN: 2001-1326
• ISSN: 2001-1326
• Language: English
• Keywords: Sample preparation; Resolution (logic); Electrospray; Chemistry; Chromatography; Artificial intelligence; Sample (material); High resolution; Mass spectrometry; Computer science; Remote sensing