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Journal article

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Abstract:

The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) receptor as a prelude to viral entry into the cell. Using a naive llama single-domain antibody library and PCR-based maturation, we have produced two closely related nanobodies, H11-D4 and H11-H4, that bind RBD (KD of 39 and 12 nM, respectively)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41594-020-0469-6

Authors


Publisher:
Springer Nature Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
27
Pages:
846–854
Place of publication:
United States
Publication date:
2020-07-13
Acceptance date:
2020-06-26
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Pmid:
32661423
Language:
English
Pubs id:
1119067
Local pid:
pubs:1119067
Deposit date:
2020-09-09

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