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Co-expression of DKK-1 and sclerostin in subchondral bone of the proximal femoral heads from osteoarthritic hips

Abstract:

Osteoarthritis (OA) is a progressively degenerative joint disease influenced by structural and metabolic factors. There is growing evidence that subchondral bone is involved in both symptomatic and structural progression in OA. The Wnt pathway has been implicated in the progression of OA but the expression and function of the Wnt inhibitors, Dikkopf (DKK-1) and sclerostin (SOST), are unclear.We examined the regional distribution of DKK-1 and SOST in subchondral bone of the femoral head using ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00223-017-0246-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
St Hildas College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Oxford college:
Wadham College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More from this funder
Grant:
Oxford Musculoskeletal Biomedical Research Unit
Publisher:
Springer US Publisher's website
Journal:
Calcified Tissue International Journal website
Volume:
100
Issue:
6
Pages:
609-618
Publication date:
2017-03-09
Acceptance date:
2017-01-30
DOI:
EISSN:
1432-0827
ISSN:
0171-967X
Pubs id:
pubs:685362
URN:
uri:4c21b004-cbe7-4b82-bcdf-8a3356dda098
UUID:
uuid:4c21b004-cbe7-4b82-bcdf-8a3356dda098
Local pid:
pubs:685362
Language:
English
Keywords:

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