Journal article
Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing
- Abstract:
- Healthy cognitive ageing is a societal and public health priority. Cerebrovascular risk factors increase the likelihood of dementia in older people but their impact on cognitive ageing in younger, healthy brains is less clear. The UK Biobank provides cognition and brain imaging measures in the largest population cohort studied to date. Here we show that cognitive abilities of healthy individuals (N = 22,059) in this sample are detrimentally affected by cerebrovascular risk factors. Structural equation modelling revealed that cerebrovascular risk is associated with reduced cerebral grey matter and white matter integrity within a fronto-parietal brain network underlying executive function. Notably, higher systolic blood pressure was associated with worse executive cognitive function in mid-life (44-69 years), but not in late-life (>70 years). During mid-life this association did not occur in the systolic range of 110-140 mmHg. These findings suggest cerebrovascular risk factors impact on brain structure and cognitive function in healthy people.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-020-18201-5
Authors
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 11
- Article number:
- 4340
- Place of publication:
- England
- Publication date:
- 2020-09-07
- Acceptance date:
- 2020-08-12
- DOI:
- EISSN:
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2041-1723
- Pmid:
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32895386
- Language:
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English
- Keywords:
- Pubs id:
-
1131234
- Local pid:
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pubs:1131234
- Deposit date:
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2020-11-19
Terms of use
- Copyright holder:
- Veldsman et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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