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Identification of lewis and blood group carbohydrate epitopes by ion mobility-tandem-mass spectrometry fingerprinting

Abstract:

Glycans have several elements that contribute to their structural complexity, involving a range of monosaccharide building blocks, configuration of linkages between residues and various degrees of branching on a given structure. Their analysis remains challenging and resolving minor isomeric variants can be difficult, in particular terminal fucosylated Lewis and blood group antigens present on N- and O-glycans. Accurately characterizing these isomeric structures by current techniques is not s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1021/acs.analchem.6b03853

Authors


Hofmann, J More by this author
Stuckmann, A More by this author
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Institution:
University of Oxford
Department:
Corpus Christi College
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Against Breast Cancer More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Analytical Chemistry Journal website
Volume:
89
Issue:
4
Pages:
2318-2325
Publication date:
2017-01-18
Acceptance date:
2017-01-18
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
Pubs id:
pubs:680527
URN:
uri:4c00048d-175a-4fda-81ca-2b2d7cc4506a
UUID:
uuid:4c00048d-175a-4fda-81ca-2b2d7cc4506a
Local pid:
pubs:680527
Language:
English
Keywords:

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