Journal article

Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence

Abstract:: Circulating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient between uterine and peripheral veins. sFlt-1 levels dropped significantly when the placenta has been removed, i.e. postnatally. This is in keeping with the placenta being the main site of sFlt-1 production in normal pregnancies.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Cerdeira, A. S., Kandzija, N., Pargmae, P., Cooke, W., James, T., Redman, C., & Vatish, M. (2019). Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: first in vivo evidence. Pregnancy Hypertension, 16(2019), 145–147.

MLA Style

Cerdeira, A. S., et al. “Circulating Soluble Fms-like Tyrosine Kinase-1 Is Placentally Derived in Normal Pregnancy: First in Vivo Evidence.” Pregnancy Hypertension, vol. 16, no. 2019, Elsevier, 2019, pp. 145–47.

Chicago Style

Cerdeira, AS, N Kandzija, P Pargmae, W Cooke, T James, C Redman, and M Vatish. 2019. “Circulating Soluble Fms-like Tyrosine Kinase-1 Is Placentally Derived in Normal Pregnancy: First in Vivo Evidence.” Pregnancy Hypertension 16 (2019): 145–47.
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Files:: Cerdeira_et_al_revised_manuscript.pdf

(Preview, Accepted manuscript, 83.0KB, Terms of use)

Publisher copy:: 10.1016/j.preghy.2019.03.013

Authors

+ Cerdeira, AS More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Role:: Author

+ Kandzija, N More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Role:: Author

+ Pargmae, P More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Role:: Author

+ Cooke, W More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Women's & Reproductive Health
Role:: Author

+ James, T More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Biochemistry
Role:: Author

More authors...

Publisher:: Elsevier
Journal:: Pregnancy Hypertension More from this journal
Volume:: 16
Issue:: 2019
Pages:: 145-147
Publication date:: 2019-03-30
Acceptance date:: 2019-03-29
DOI:: 10.1016/j.preghy.2019.03.013
EISSN:: 2210-7797
ISSN:: 2210-7789
Pmid:: 31056150

Language:: English
Keywords:: placenta

pregnancy

uterine vein

preeclampsia

sFlt-1

FFR
Pubs id:: pubs:995411
UUID:: uuid:4bf33c13-19c0-47f0-8b76-c28d9c8327c4
Local pid:: pubs:995411
Source identifiers:: 995411
Deposit date:: 2019-06-11

Terms of use

Copyright holder:: International Society for the Study of Hypertension in Pregnancy
Copyright date:: 2019
Rights statement:: © 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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