Journal article

Peptide nucleic acid probes with charged photocleavable mass markers: Towards PNA-based MALDI-TOF MS genetic analysis.

Abstract:: Halogen-labelled peptide organic acid (HPOA) monomers have been synthesised and incorporated into sequence-specific peptide nucleic acid (PNA) probes. Three different types of probe have been prepared; the unmodified PNA probe, the PNA probe with a mass marker, and the PNA probe with photocleavable mass marker. All three types of probe have been used in model studies to develop a mass spectrometry-based hybridisation assay for detection of point mutations in DNA.

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APA Style

Ball, R., Green, P., Gale, N., Langley, G., & Brown, T. (2010). Peptide nucleic acid probes with charged photocleavable mass markers: Towards PNA-based MALDI-TOF MS genetic analysis. Artificial DNA, PNA and XNA, 1(1), 27–35.

MLA Style

Ball, R., et al. “Peptide Nucleic Acid Probes with Charged Photocleavable Mass Markers: Towards PNA-Based MALDI-TOF MS Genetic Analysis.” Artificial DNA, PNA and XNA, vol. 1, no. 1, 2010, pp. 27–35.

Chicago Style

Ball, R, P Green, N Gale, G Langley, and T Brown. 2010. “Peptide Nucleic Acid Probes with Charged Photocleavable Mass Markers: Towards PNA-Based MALDI-TOF MS Genetic Analysis.” Artificial DNA, PNA and XNA 1 (1): 27–35.
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Publisher copy:: 10.4161/adna.1.1.12199

Authors

+ Ball, R More by this author

Role:: Author

+ Green, P More by this author

Role:: Author

+ Gale, N More by this author

Role:: Author

+ Langley, G More by this author

Role:: Author

+ Brown, T More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Artificial DNA, PNA and XNA More from this journal
Volume:: 1
Issue:: 1
Pages:: 27-35
Publication date:: 2010-07-01
DOI:: 10.4161/adna.1.1.12199
EISSN:: 1949-0968
ISSN:: 1949-095X

Language:: English
Keywords:: Photocleavable mass marker tag

SNP

Peptide nucleic acid

Halogen-labelled peptide organic acid

Genetic analysis
Pubs id:: pubs:399989
UUID:: uuid:4be32682-3928-4bab-a752-90c6dca93b33
Local pid:: pubs:399989
Source identifiers:: 399989
Deposit date:: 2013-11-16

Terms of use

Copyright date:: 2010

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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