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Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha.

Abstract:

BACKGROUND: In patients with louse-borne relapsing fever (Borrelia recurrentis infection), antimicrobial treatment is often followed by sudden fever, rigors, and persistent hypotension (Jarisch-Herxheimer reactions) that are associated with increases in plasma concentrations of tumor necrosis factor alpha (TNF-alpha), interleukin-6, and interleukin-8. We attempted to determine whether sheep polyclonal Fab antibody fragments against TNF-alpha (anti-TNF-alpha Fab) could suppress the Jarisch-Her...

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Publication status:
Published

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Publisher copy:
10.1056/nejm199608013350503

Authors


Hussein, K More by this author
Lalloo, DG More by this author
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Journal:
The New England journal of medicine
Volume:
335
Issue:
5
Pages:
311-315
Publication date:
1996-08-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:4be1d667-c6ae-42a0-abc8-b953df9e46a8
Source identifiers:
61180
Local pid:
pubs:61180

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