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Journal article

Efficient transmission and persistence of low-frequency SIVmac251 variants in CD8-depleted rhesus macaques with different neuropathology.

Abstract:

Infection of CD8-depleted rhesus macaques with the genetically heterogeneous simian immunodeficiency virus (SIV)mac251 viral swarm provides a rapid-disease model for simian acquired immune deficiency syndrome and SIV-encephalitis (SIVE). The objective was to evaluate how the diversity of the swarm influences the initial seeding of the infection that may potentially affect disease progression. Plasma, lymphoid and non-lymphoid (brain and lung) tissues were collected from two infected macaques ...

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Publisher copy:
10.1099/vir.0.039586-0

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Journal:
The Journal of general virology
Volume:
93
Issue:
Pt 5
Pages:
925-938
Publication date:
2012-05-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:4bcf485d-95ac-4f4b-b17c-2124ca573a27
Source identifiers:
315468
Local pid:
pubs:315468

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