Journal article icon

Journal article

Experimental treatment of Ebola virus disease with TKM-130803: A single-arm phase 2 clinical trial.

Abstract:

Background

TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated.

Methods and Findings

In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of TKM-130803 by intravenous infusion once daily for up to 7 d. On days when trial enrolment capacity was reached, patients were enrolled into a concurre...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.1001997

Authors


More by this author
Department:
Oxford, MSD, NDM, Tropical Medicine
More by this author
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
More by this author
Department:
Oxford, MSD, NDM, Tropical Medicine
Expand authors...
Department for International Development More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
13
Issue:
4
Pages:
e1001997
Publication date:
2016-04-05
Acceptance date:
2016-03-08
DOI:
ISSN:
1549-1676 and 1549-1277
Pubs id:
pubs:616748
URN:
uri:4b9f83ce-449a-479d-9230-f6aaf978e553
UUID:
uuid:4b9f83ce-449a-479d-9230-f6aaf978e553
Local pid:
pubs:616748

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP