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Journal article

Interleukin-23 drives intestinal inflammation through direct activity on T cells.

Abstract:

Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, we demonstrated that T cell reactivity to IL-23 was critical for development of intestinal pathology, but not for systemic inflammation. Through direct signaling into T cells, IL-...

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Publication status:
Published

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Journal:
Immunity
Volume:
33
Issue:
2
Pages:
279-288
Publication date:
2010-08-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Source identifiers:
67490
Language:
English
Keywords:
Pubs id:
pubs:67490
UUID:
uuid:4b9997f9-96b4-422b-9eff-fa5341a1b11e
Local pid:
pubs:67490
Deposit date:
2012-12-19

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