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The cysteinome of protein kinases as a target in drug development

Abstract:

Drugs that function through covalent bond formation represent a considerable fraction of our repository of effective medicines but safety concerns and the complexity of developing covalent inhibitors has rendered covalent targeting a less attractive strategy for rational drug design. The recent approval of four covalent kinase inhibitors and the development of highly potent covalent kinase probes with exceptional selectivity has raised significant interest in industry and academic research an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201707875

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0003-4620-4650
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
Role:
Author
ORCID:
0000-0001-5995-6494
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
57
Issue:
16
Pages:
4372-4385
Publication date:
2018-02-02
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Pubs id:
pubs:823431
URN:
uri:4b843511-88c2-45a9-8668-77a6693cf685
UUID:
uuid:4b843511-88c2-45a9-8668-77a6693cf685
Local pid:
pubs:823431

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