Journal article

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms

Abstract:: Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Gifford, V., & Itoh, Y. (2019). MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms. Biochemical Society Transactions, 47(3), 811–826.

MLA Style

Gifford, V., and Y. Itoh. “MT1-MMP-Dependent Cell Migration: Proteolytic and Non-Proteolytic Mechanisms.” Biochemical Society Transactions, vol. 47, no. 3, Portland Press, 2019, pp. 811–26.

Chicago Style

Gifford, V, and Y Itoh. 2019. “MT1-MMP-Dependent Cell Migration: Proteolytic and Non-Proteolytic Mechanisms.” Biochemical Society Transactions 47 (3): 811–26.
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Files:: MT1-MMP-dependent cell migration.pdf

(Preview, Version of record, pdf, 974.7KB, Terms of use)

Publisher copy:: 10.1042/BST20180363

Authors

+ Gifford, V More by this author

Role:: Author

+ Itoh, Y More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Kennedy Institute for Rheumatology
Role:: Author

Publisher:: Portland Press
Journal:: Biochemical Society Transactions More from this journal
Volume:: 47
Issue:: 3
Pages:: 811-826
Publication date:: 2019-05-07
Acceptance date:: 2019-04-08
DOI:: 10.1042/BST20180363
ISSN:: 0300-5127

Keywords:: FFR
Pubs id:: pubs:991370
UUID:: uuid:4b682a88-42c5-466a-8f75-7eef27ef4d21
Local pid:: pubs:991370
Source identifiers:: 991370
Deposit date:: 2019-04-16

Terms of use

Copyright holder:: Gifford et Itoh
Copyright date:: 2019
Notes:: © 2019 The Author(s)
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).

Licence:: CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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