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The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.

Abstract:

Potassium channels selectively conduct K(+) ions across cell membranes and have key roles in cell excitability. Their opening and closing can be spontaneous or controlled by membrane voltage or ligand binding. We used Ba(2+) as a probe to determine the location of the ligand-sensitive gate in an inwardly rectifying K(+) channel (Kir6.2). To a K(+) channel, Ba(2+) and K(+) are of similar sizes, but Ba(2+) blocks the pore by binding within the selectivity filter. We found that internal Ba(2+) c...

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Publisher copy:
10.1038/sj.embor.embor708

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
EMBO reports
Volume:
4
Issue:
1
Pages:
70-75
Publication date:
2003-01-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:4b3d684e-3da2-48cc-bab0-4e286e599083
Source identifiers:
114062
Local pid:
pubs:114062

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