Journal article
The oscillation of mitotic kinase governs cell cycle latches in mammalian cells
- Abstract:
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The mammalian cell cycle alternates between two phases: S-G2-M with high levels of A- and B-type cyclin-dependent kinases (CycA,B:CDK); and G1 with persistent degradation of CycA,B by Cdh1-activated APC/C (anaphase promoting complex/cyclosome). Because CDKs phosphorylate and inactivate Cdh1, these two phases are mutually exclusive. This 'toggle switch' is flipped from G1 to S by cyclin-E (CycE:CDK), which is not degraded by Cdh1:APC/C; and from M to G1 by Cdc20:APC/C, which is not inactivated...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 8.6MB, Terms of use)
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- Publisher copy:
- 10.1242/jcs.261364
Authors
Bibliographic Details
- Publisher:
- Company of Biologists
- Journal:
- Journal of Cell Science More from this journal
- Volume:
- 137
- Issue:
- 3
- Article number:
- jcs261364
- Place of publication:
- England
- Publication date:
- 2024-01-11
- Acceptance date:
- 2023-12-29
- DOI:
- EISSN:
-
1477-9137
- ISSN:
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0021-9533
- Pmid:
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38206091
Item Description
- Language:
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English
- Keywords:
- Pubs id:
-
1602580
- Local pid:
-
pubs:1602580
- Deposit date:
-
2024-01-23
Terms of use
- Copyright holder:
- Dragoi et al
- Copyright date:
- 2024
- Rights statement:
- © 2024. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Licence:
- CC Attribution (CC BY)
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