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Journal article

High levels of virus-specific CD4+ T cells predict severe pandemic influenza A virus infection.

Abstract:

RATIONALE: T-cell responses have been implicated in control and exacerbation of lung injury during influenza A virus (IAV) infection. OBJECTIVES: To examine the breadth and magnitude of influenza-specific CD4(+) and CD8(+) T-cell responses during acute phase of infection. METHODS: Influenza-specific T-cell response to the entire pandemic H1N1/09 IAV proteome and T cell-related cytokine levels were measured in blood from previously healthy individuals with mild (n = 32) and severe (n = 16) IAV...

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Publication status:
Published

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Publisher copy:
10.1164/rccm.201207-1245oc

Authors


Powell, TJ More by this author
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Journal:
American journal of respiratory and critical care medicine
Volume:
186
Issue:
12
Pages:
1292-1297
Publication date:
2012-12-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:4b085dd7-7ee8-4e9c-84c7-d22a0e7d8a87
Source identifiers:
367629
Local pid:
pubs:367629

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