Journal article

Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.

Abstract:: The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Lindegardh, N., Davies, G., Tran, T., Farrar, J., Singhasivanon, P., Day, N., & White, N. (2006). Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases. Antimicrobial Agents and Chemotherapy, 50(9), 3197–3199.

MLA Style

Lindegardh, N., et al. “Rapid Degradation of Oseltamivir Phosphate in Clinical Samples by Plasma Esterases.” Antimicrobial Agents and Chemotherapy, vol. 50, no. 9, 2006, pp. 3197–99.

Chicago Style

Lindegardh, N, G Davies, T Tran, J Farrar, P Singhasivanon, N Day, and N White. 2006. “Rapid Degradation of Oseltamivir Phosphate in Clinical Samples by Plasma Esterases.” Antimicrobial Agents and Chemotherapy 50 (9): 3197–99.
Share
Print

Access Document

Publisher copy:: 10.1128/aac.00500-06

Authors

+ Lindegardh, N More by this author

Role:: Author

+ Davies, G More by this author

Role:: Author

+ Tran, T More by this author

Role:: Author

+ Farrar, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Tropical Medicine
Role:: Author

+ Singhasivanon, P More by this author

Role:: Author

More authors...

Journal:: Antimicrobial agents and chemotherapy More from this journal
Volume:: 50
Issue:: 9
Pages:: 3197-3199
Publication date:: 2006-09-01
DOI:: 10.1128/aac.00500-06
EISSN:: 1098-6596
ISSN:: 0066-4804

Language:: English
Keywords:: Esterases

Antiviral Agents

Oseltamivir

Adult

Male

Female

Organophosphates

Humans

Prodrugs
Pubs id:: pubs:27915
UUID:: uuid:4ad0f9ea-adf1-4b88-b8b6-89143f5e682d
Local pid:: pubs:27915
Source identifiers:: 27915
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2006

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP