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Journal article

Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation.

Abstract:

How transcription factors interpret the output from signal transduction pathways to drive distinct programs of gene expression is a key issue that underpins development and disease. The ubiquitously expressed basic-helix-loop-helix leucine zipper upstream stimulating factor-1 binds E-box regulatory elements (CANNTG) to regulate a wide number of gene networks. In particular, USF-1 is a key component of the tanning process. Following UV irradiation, USF-1 is phosphorylated by the p38 stress-act...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m808605200

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
284
Issue:
28
Pages:
18851-18862
Publication date:
2009-07-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
41307

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