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Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect?

Abstract:

Recent evidence suggests that a mutation of the glucagon receptor (GCG-R) gene is involved in the development of type 2 diabetes in French patients. We have examined patients from three geographically distinct regions in the UK and found the GGT40 (Gly) to AGT40 (Ser) mutation to be present in 15/691 (2.2%) of patients with type 2 (non-insulin dependent) diabetes and 1/425 (0.2%) of geographically matched controls and have therefore replicated association of the GCG-R mutation with classical ...

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Publisher copy:
10.1093/hmg/4.9.1609

Authors


Pritchard, LE More by this author
Merriman, TR More by this author
Merriman, ME More by this author
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Journal:
Human molecular genetics
Volume:
4
Issue:
9
Pages:
1609-1612
Publication date:
1995-09-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:4a9f207c-822b-474f-89b4-73bf0af0664f
Source identifiers:
176242
Local pid:
pubs:176242

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