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Targeting micrometastases: The effect of heterogeneous radionuclide distribution on tumor control probability

Abstract:

The spatial distribution of radiopharmaceuticals that emit short-range high linear-energy-transfer electrons greatly affects absorbed dose and biological effectiveness. The purpose of this study was to investigate the effect of heterogeneous radionuclide distribution on tumor control probability (TCP) in a micrometastasis model. Methods: The cancer cell lines MDA-MB-468, SQ20B, and 231-H2N were grown as spheroids to represent micrometastases. The intracellular distribution of a representative...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.2967/jnumed.117.207308

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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Publisher:
Society of Nuclear Medicine Publisher's website
Journal:
Journal of Nuclear Medicine Journal website
Volume:
60
Issue:
2
Pages:
250-258
Publication date:
2018-06-29
Acceptance date:
2018-06-07
DOI:
EISSN:
2159-662X
ISSN:
0161-5505
Pubs id:
pubs:856915
URN:
uri:4a9e22cd-8b33-4184-a646-c6f57f731b1a
UUID:
uuid:4a9e22cd-8b33-4184-a646-c6f57f731b1a
Local pid:
pubs:856915

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