Importance of matrix metalloproteinases in human trophoblast invasion.

Journal article

Human cytotrophoblast cells are invasive by virtue of their ability to secrete metalloproteinases (MMP) capable of digesting the extracellular matrix of the endometrium. It is the aim of the present study to determine which of the known MMP is responsible for this invasive behavior and to see to what extent endometrial secretions can modulate this enzymatic activity. Under our experimental conditions, first-trimester cytotrophoblast cells invade matrigel; this invasive behavior is inhibited b...

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Authors: Bischof, P; Martelli, M; Campana, A; Itoh, Y; Ogata, Y

• Journal: Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy
• Volume: 1
• Issue: 4
• Pages: 263-269
• Publication date: 1995-12-01
• ISSN: 1354-4195
• Language: English
• Keywords: Female; Cells, Cultured; Culture Media, Conditioned; Antibodies; Laminin; Humans; Metalloendopeptidases; Mice; Proteoglycans; Pregnancy; Collagen; Pregnancy Trimester, First; Protease Inhibitors; Gelatinases; Drug Combinations; Trophoblasts; Animals; Kinetics; Endometrium; Phenanthrolines; Extracellular Matrix