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Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.

Abstract:

BACKGROUND: Chlorproguanil-dapsone exerts lower resistance pressure on Plasmodium falciparum than does sulfadoxine-pyrimethamine, but is rapidly eliminated. We aimed to find out whether chlorproguanil-dapsone results in a higher retreatment rate for malaria than sulfadoxine-pyrimethamine. METHODS: In a randomised trial of paediatric outpatients with uncomplicated falciparum malaria, patients received either chlorproguanil-dapsone or sulfadoxine-pyrimethamine and were followed up for up to 1 ...

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Publication status:
Published

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Authors


Chimpeni, P More by this author
Hatcher, J More by this author
Kublin, JG More by this author
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Journal:
Lancet
Volume:
360
Issue:
9340
Pages:
1136-1143
Publication date:
2002-10-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:4a8e54f7-4fcf-4b45-8462-52928d3be30a
Source identifiers:
38429
Local pid:
pubs:38429

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