The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort

Franklin, HD; Russell, LL; Peakman, G; Greaves, CV; Bocchetta, M; Nicholas, J; Poos, J; Convery, RS; Cash, DM; van Swieten, J; Jiskoot, L; Moreno, F; Sanchez-Valle, R; Borroni, B; Laforce, R; Masellis, M; Tartaglia, MC; Graff, C; Galimberti, D; Rowe, JB; Finger, E; Synofzik, M; Vandenberghe, R; de Mendonça, A; Tagliavini, F; Butler, C

Neuroscience & Neuroimaging Research Collection

Journal article

The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort

Abstract:: BACKGROUND: Inappropriate trusting behaviour may have significant social, financial and other consequences for people living with dementia. However, its clinical associations and predictors have not been clarified. Here we addressed this issue in canonical syndromes of frontotemporal dementia (FTD) and Alzheimer’s disease (AD). METHODS: In 34 patients with AD and 73 with FTD (27 behavioural variant (bv)FTD, 22 semantic variant primary progressive aphasia (svPPA), 24 nonfluent/agrammatic variant (nfv)PPA) we recorded inappropriate trusting and other abnormal socio-emotional behaviours using a semi-structured caregiver survey. Patients were comprehensively characterised using a general cognitive assessment and the Revised Self-Monitoring Scale (RSMS; an informant index of socioemotional awareness). RESULTS: Inappropriate trusting was more frequent in svPPA (55%) and bvFTD (44%) than nfvPPA (17%) or AD (24%). After adjusting for age, sex, education and Mini-Mental State Examination (MMSE) score, inappropriate trusting was significantly more likely in svPPA (odds ratio 3.61; 95% confidence interval 1.41–8.75) and bvFTD (3.01, 1.23–6.65) than AD. Significant predictors of inappropriate trusting comprised apathy in svPPA, disinhibition and altered pain responsiveness in bvFTD, and lower MMSE and RSMS (self-presentation) scores in AD. CONCLUSION: Dementia syndromes vary in prevalence and predictors of abnormal trusting behaviour, with implications for clinical counselling and safeguarding

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Franklin, H. D., Russell, L. L., Peakman, G., Greaves, C. V., Bocchetta, M., Nicholas, J., Poos, J., Convery, R. S., Cash, D. M., van Swieten, J., Jiskoot, L., Moreno, F., Sanchez-Valle, R., Borroni, B., Laforce, R., Masellis, M., Tartaglia, M. C., Graff, C., Galimberti, D., … Butler, C. (2021). The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort. Alzheimer's Research & Therapy, 13(1), 127–127.

MLA Style

Franklin, HD, et al. “The Revised Self-Monitoring Scale Detects Early Impairment of Social Cognition in Genetic Frontotemporal Dementia within the GENFI Cohort.” Alzheimer's Research & Therapy, vol. 13, no. 1, 2021, pp. 127–27.

Chicago Style

Franklin, HD, LL Russell, G Peakman, et al. 2021. “The Revised Self-Monitoring Scale Detects Early Impairment of Social Cognition in Genetic Frontotemporal Dementia within the GENFI Cohort.” Alzheimer's Research & Therapy 13 (1): 127–27.
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