Journal article icon

Journal article

In vitro cellular models of human hepatic fatty acid metabolism: differences between Huh7 and HepG2 cell lines in human and fetal bovine culturing serum

Abstract:

Human primary hepatocytes are the gold standard for investigating lipid metabolism in non-alcoholic fatty liver disease (NAFLD); however, due to limitations including availability and donor variability, the hepatoma cell lines Huh7 and HepG2 are commonly used. Culturing these cell lines in human serum (HS) has been reported to improve functionality; however, direct comparison of fatty acid (FA) metabolism in response to culturing in HS is lacking. The aim of this study was to compare FA metab...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.14814/phy2.13532

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Pramfalk, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Publisher:
Wiley Publisher's website
Journal:
Physiological Reports Journal website
Volume:
5
Issue:
24
Pages:
Article: 13532
Publication date:
2017-12-21
Acceptance date:
2017-11-05
DOI:
ISSN:
2051-817X
Pubs id:
pubs:743630
URN:
uri:4a740ac5-0cff-4137-8387-82afee832a96
UUID:
uuid:4a740ac5-0cff-4137-8387-82afee832a96
Local pid:
pubs:743630

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP