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In vitro cellular models of human hepatic fatty acid metabolism: differences between Huh7 and HepG2 cell lines in human and fetal bovine culturing serum

Abstract:

Human primary hepatocytes are the gold standard for investigating lipid metabolism in non-alcoholic fatty liver disease (NAFLD); however, due to limitations including availability and donor variability, the hepatoma cell lines Huh7 and HepG2 are commonly used. Culturing these cell lines in human serum (HS) has been reported to improve functionality; however, direct comparison of fatty acid (FA) metabolism in response to culturing in HS is lacking. The aim of this study was to compare FA metab...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.14814/phy2.13532

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Physiological Reports Journal website
Volume:
5
Issue:
24
Pages:
Article: 13532
Publication date:
2017-12-21
Acceptance date:
2017-11-05
DOI:
ISSN:
2051-817X
Pubs id:
pubs:743630
URN:
uri:4a740ac5-0cff-4137-8387-82afee832a96
UUID:
uuid:4a740ac5-0cff-4137-8387-82afee832a96
Local pid:
pubs:743630
Paper number:
24

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