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Anti-thrombin is expressed in the benign prostatic epithelium and in prostate cancer and is capable of forming complexes with prostate-specific antigen and human glandular kallikrein 2.

Abstract:

Anti-thrombin, a member of the serpin family and an inhibitor of thrombin and blood coagulation factor Xa, was recently shown to inhibit angiogenesis and tumor growth. In the present study, we examined the expression of anti-thrombin in benign and malignant prostate gland. Using immunohistochemistry, anti-thrombin was found in prostate epithelium and stroma cells. Tissue microarrays of tumors (n = 112) and three different prostate cancer cell lines (PC-3, LNCaP, and DU-145) were all positive ...

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Authors


Lundwall, A More by this author
Gadaleanu, V More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Bjartell, A More by this author
Journal:
The American journal of pathology
Volume:
161
Issue:
6
Pages:
2053-2063
Publication date:
2002-12-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:4a7382da-ac52-4992-8ffc-e91a63280f23
Source identifiers:
366018
Local pid:
pubs:366018

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