Journal article : Review

Immune-mediated cardiac development and regeneration

Abstract:: The complex interplay between the immune and cardiovascular systems during development, homeostasis and regeneration represents a rapidly evolving field in cardiac biology. Single cell technologies, spatial mapping and computational analysis have revolutionised our understanding of the diversity and functional specialisation of immune cells within the heart. From the earliest stages of cardiogenesis, where primitive macrophages guide heart tube formation, to the complex choreography of inflammation and its resolution during regeneration, immune cells emerge as central orchestrators of cardiac fate. Translating these fundamental insights into clinical applications represents a major challenge and opportunity for the field. In this Review, we decode the immunological blueprint of heart development and regeneration to transform cardiovascular disease treatment and unlock the regenerative capacity of the human heart.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Byatt, T. C., Razaghi, E., Tüzüner, S., & Simões, F. C. (2025). Immune-mediated cardiac development and regeneration. Seminars in Cell and Developmental Biology, 171.

MLA Style

Byatt, TC, et al. “Immune-Mediated Cardiac Development and Regeneration.” Seminars in Cell and Developmental Biology, vol. 171, 2025.

Chicago Style

Byatt, TC, E Razaghi, S Tüzüner, and FC Simões. 2025. “Immune-Mediated Cardiac Development and Regeneration.” Seminars in Cell and Developmental Biology 171.
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Files:: Byatt_et_al_2025_Immune_mediated_cardiac.pdf

(Preview, Version of record, pdf, 4.3MB, Terms of use)

Publisher copy:: 10.1016/j.semcdb.2025.103613

Authors

+ Byatt, TC More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Physiology Anatomy and Genetics
Role:: Author

+ Razaghi, E More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Physiology Anatomy and Genetics
Sub department:: IDRM (DPAG)
Role:: Author

+ Tüzüner, S More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Physiology Anatomy and Genetics
Sub department:: IDRM (DPAG)
Role:: Author

+ Simões, FC More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Physiology Anatomy and Genetics
Sub department:: IDRM (DPAG)
Oxford college:: Kellogg College
Role:: Author
ORCID:: 0000-0003-2956-0311

+ British Heart Foundation More from this funder

Funder identifier:: https://ror.org/02wdwnk04
Grant:: FS/IBSRF/21/25088

+ Biotechnology and Biological Sciences Research Council More from this funder

Funder identifier:: https://ror.org/00cwqg982
Grant:: BB/Y003179/1

Publisher:: Elsevier
Journal:: Seminars in Cell and Developmental Biology More from this journal
Volume:: 171
Article number:: 103613
Place of publication:: England
Publication date:: 2025-05-01
Acceptance date:: 2025-04-16
DOI:: 10.1016/j.semcdb.2025.103613
EISSN:: 1096-3634
ISSN:: 1084-9521
Pmid:: 40315634

Language:: English
Keywords:: immune cells

cardiac niche

development

regeneration

heart
Subtype:: Review
Pubs id:: 2121631
Local pid:: pubs:2121631
Deposit date:: 2025-05-06
ARK identifier:: ark:/29072/ora_4a55ca1121374bd2bee7d724993e0085

Terms of use

Copyright holder:: Byatt et al
Copyright date:: 2025
Rights statement:: © 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Licence:: CC Attribution (CC BY)

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