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Structure of the Lassa virus glycan shield provides a model for immunological resistance

Abstract:

Lassa virus is an Old World arenavirus endemic to West Africa that causes severe hemorrhagic fever. Vaccine development has focused on the envelope glycoprotein complex (GPC) that extends from the virion envelope. The often inadequate antibody immune response elicited by both vaccine and natural infection has been, in part, attributed to the abundance of N-linked glycosylation on the GPC. Here, using a virus-like-particle system that presents Lassa virus GPC in a native-like context, we deter...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1803990115

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; BDI-NDM
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0002-9353-0355
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Bill and Melinda Gates Foundation More from this funder
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
28
Pages:
7320-7325
Publication date:
2018-06-25
Acceptance date:
2018-06-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:859620
URN:
uri:4a3a95c7-495a-4c21-b11d-d171350aeb56
UUID:
uuid:4a3a95c7-495a-4c21-b11d-d171350aeb56
Local pid:
pubs:859620

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