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Design, synthesis, structure-activity relationship studies, and three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling of a series of O-biphenyl carbamates as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase

Abstract:

We recently reported molecules designed according to the multitarget-directed ligand paradigm to exert combined activity at human fatty acid amide hydrolase (FAAH) and dopamine receptor subtype D3 (D3R). Both targets are relevant for tackling several types of addiction (most notably nicotine addiction) and other compulsive behaviors. Here, we report an SAR exploration of a series of biphenyl-N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates, a novel class of molecules that had ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.jmedchem.6b01578

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Department:
Wadham College
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Medicinal Chemistry Journal website
Volume:
60
Issue:
6
Pages:
2287-2304
Publication date:
2017-02-09
Acceptance date:
2017-02-09
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Pubs id:
pubs:684981
URN:
uri:4a390632-521d-4c5e-8546-e2616065782c
UUID:
uuid:4a390632-521d-4c5e-8546-e2616065782c
Local pid:
pubs:684981
Paper number:
6
Language:
English

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