Journal article
Formation of quaternary centers by copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents.
- Abstract:
- Pure and simple: Alkylzirconocenes generated in situ from simple alkenes are used in highly enantioselective copper-catalyzed 1,4-addition reactions to trisubstituted cyclic enones to generate quaternary centers. These reactions operate at room temperature under a range of conditions and tolerate many functional groups. Cp=cyclopentadienyl, Tf=trifluoromethanesulfonyl. Copyright © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 656.2KB, Terms of use)
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- Publisher copy:
- 10.1002/anie.201303202
Authors
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie (International ed. in English) More from this journal
- Volume:
- 52
- Issue:
- 31
- Pages:
- 7995-7999
- Publication date:
- 2013-07-01
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:407851
- UUID:
-
uuid:49f1680f-ebb2-4fd8-aa78-33ef830d61f9
- Local pid:
-
pubs:407851
- Source identifiers:
-
407851
- Deposit date:
-
2013-11-17
Terms of use
- Copyright holder:
- WILEY-VCH Verlag GmbH and Co KGaA, Weinheim
- Copyright date:
- 2013
- Notes:
-
Copyright © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. This is the accepted version of the following article: Sidera, M., Roth, P. M. C., Maksymowicz, R. M. and Fletcher, S. P. (2013), Formation of Quaternary Centers by Copper-Catalyzed Asymmetric Conjugate Addition of Alkylzirconium Reagents . Angew. Chem. Int. Ed., 52: 7995–7999.,
which has been published in final form at http://dx.doi.org/10.1002/anie.201303202.
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