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Journal article

Formation of quaternary centers by copper-catalyzed asymmetric conjugate addition of alkylzirconium reagents.

Abstract:
Pure and simple: Alkylzirconocenes generated in situ from simple alkenes are used in highly enantioselective copper-catalyzed 1,4-addition reactions to trisubstituted cyclic enones to generate quaternary centers. These reactions operate at room temperature under a range of conditions and tolerate many functional groups. Cp=cyclopentadienyl, Tf=trifluoromethanesulfonyl. Copyright © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201303202

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie (International ed. in English) Journal website
Volume:
52
Issue:
31
Pages:
7995-7999
Publication date:
2013-07-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Source identifiers:
407851
Language:
English
Keywords:
Pubs id:
pubs:407851
UUID:
uuid:49f1680f-ebb2-4fd8-aa78-33ef830d61f9
Local pid:
pubs:407851
Deposit date:
2013-11-17

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