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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

Abstract:

Protein kinase casein kinase 2 (CK2) is a serine/threonine kinase with evidence of implication in growth dysregulation and apoptosis resistance, making it a relevant target for cancer therapy. Several CK2 inhibitors have been developed showing variable efficiency, emphasizing the need to expand the chemical diversity of those inhibitors. We report the identification and characterization of 2,8-difurandicarboxylic acid derivatives as a new class of nanomolar ATP-competitive inhibitors. Selecti...

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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
24
Issue:
9
Pages:
3171-85
Publication date:
2010-01-01
ISSN:
1530-6860

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