Journal article
Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.
- Abstract:
-
A variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T locus and an additional two cases showed focal amplification; 70/181 (39%) tumours were polysomic for chromosome 6, and 8/181 (4.5%) primary tumours showed a minor allelic gain of T as assessed by FISH. No germline alteration of the T locus was identi...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/path.2816
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Bibliographic Details
- Journal:
- The Journal of pathology
- Volume:
- 223
- Issue:
- 3
- Pages:
- 327-335
- Publication date:
- 2011-02-05
- DOI:
- EISSN:
-
1096-9896
- ISSN:
-
0022-3417
- URN:
-
uuid:49c235c8-1b6f-4b2a-9286-88a812f9d265
- Source identifiers:
-
110416
- Local pid:
- pubs:110416
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2011
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