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Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Abstract:

A variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T locus and an additional two cases showed focal amplification; 70/181 (39%) tumours were polysomic for chromosome 6, and 8/181 (4.5%) primary tumours showed a minor allelic gain of T as assessed by FISH. No germline alteration of the T locus was identi...

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Publication status:
Published

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Publisher copy:
10.1002/path.2816

Authors


Presneau, N More by this author
Shalaby, A More by this author
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Journal:
The Journal of pathology
Volume:
223
Issue:
3
Pages:
327-335
Publication date:
2011-02-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:49c235c8-1b6f-4b2a-9286-88a812f9d265
Source identifiers:
110416
Local pid:
pubs:110416

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