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Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains

Abstract:

Protocadherins 11X and 11Y are cell adhesion molecules of the δ1-protocadherin family. Pcdh11X is present throughout the mammalian radiation; however, 6 million years ago (MYA), a reduplicative translocation of the Xq21.3 block onto what is now human Yp11 created the Homo sapiens-specific PCDH11Y. Therefore, modern human females express PCDH11X whereas males express both PCDH11X and PCDH11Y. PCDH11X/Y has been subject to accelerated evolution resulting in human-specific changes to...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cercor/bhs181

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Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
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Publisher:
Oxford University Press Publisher's website
Journal:
Cerebral Cortex Journal website
Volume:
23
Issue:
8
Pages:
1933–1941
Publication date:
2013-08-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:49a3d1eb-3142-415a-b95f-379db93dde1a
Local pid:
ora:8047

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