Journal article
Electronics with shape actuation for minimally invasive spinal cord stimulation
- Abstract:
- Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead–type devices, which can be implanted via simple needle puncture under local anesthetic but offer clinical drawbacks when compared with paddle devices. By applying photo- and soft lithography fabrication, we have developed a device that features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle-type conformation. The device and implantation procedure have been validated in vitro and on human cadaver models. This device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are implanted in patients percutaneously in a minimally invasive fashion.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.9MB, Terms of use)
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(Supplementary materials, zip, 7.6MB, Terms of use)
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- Publisher copy:
- 10.1126/sciadv.abg7833
Authors
+ European Commission
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- Funder identifier:
- https://ror.org/00k4n6c32
- Grant:
- 732032
- Programme:
- ECH2020 FET BrainCom
+ National Institute for Health and Care Research
More from this funder
- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- CL-2019-14-004
- Programme:
- HEE/NIHR ICA Program
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- RG84584
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- https://ror.org/0439y7842
- Grant:
- EP/L015889/1
- EP/S023046/1
- RG90413
+ Biotechnology and Biological Sciences Research Council
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- Funder identifier:
- https://ror.org/00cwqg982
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science Advances More from this journal
- Volume:
- 7
- Issue:
- 26
- Article number:
- eabg7833
- Publication date:
- 2021-06-25
- Acceptance date:
- 2021-05-13
- DOI:
- EISSN:
-
2375-2548
- Language:
-
English
- Pubs id:
-
1280271
- Local pid:
-
pubs:1280271
- Source identifiers:
-
W3167842833
- Deposit date:
-
2026-05-12
- ARK identifier:
Terms of use
- Copyright holder:
- Woodington et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors, somerights reserved; exclusive licen see American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
- Licence:
- CC Attribution (CC BY)
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