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Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus.

Abstract:

Type 2 diabetes mellitus (T2-DM) markedly increases the incidence of ischemic heart disease (IHD) and, consequently, mortality. However, the underlying mechanisms leading to IHD in T2-DM are not completely understood. We hypothesized that in T2-DM the regulation of coronary microvascular resistance by local mechanisms is altered. Thus, in coronary arterioles (diameter: approximately 80 microm) isolated from male mice with T2-DM (C57BL/KsJ-db/db) and control littermates, responses to changes i...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00235.2003

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
285
Issue:
4
Pages:
H1404-H1410
Publication date:
2003-10-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:49801747-0c19-4727-81f4-463b2d5c4efb
Source identifiers:
164471
Local pid:
pubs:164471

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