Journal article
Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains
- Abstract:
- The mammalian brain orchestrates the processing and integration of information to guide behaviour. Here, to characterize mammalian information-processing architecture, we combine functional neuroimaging and anaesthesia in humans, macaques, marmosets and mice. We show that breakdown of information integration is a convergent effect of diverse anaesthetics across mammalian species. As the system disintegrates, brain dynamics become more difficult to control. Both effects are reversed upon re-awakening induced by thalamic deep-brain stimulation in the macaque. Regional breakdown of integrated information coincides with the species-specific spatial topography of PVALB/Pvalb gene expression. To provide mechanistic insight beyond correlation, we develop computational models for humans, macaques and mice that integrate species-specific connectivity and transcriptomic gradients, demonstrating their respective roles for controlling brain dynamics and information integration. We reveal evolutionarily conserved controllers of information integration in the mammalian brain.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 11.8MB, Terms of use)
-
- Publisher copy:
- 10.1038/s41562-025-02381-5
Authors
+ Gates Cambridge Trust
More from this funder
- Funder identifier:
- https://ror.org/033sn5p83
- Funding agency for:
- Luppi, AI
- Grant:
- OPP 1144
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Funding agency for:
- Luppi, AI
- Grant:
- 226924/Z/23/Z
+ University of Cambridge
More from this funder
- Funder identifier:
- https://ror.org/013meh722
- Funding agency for:
- Luppi, AI
- Publisher:
- Nature Research
- Journal:
- Nature Human Behaviour More from this journal
- Publication date:
- 2026-01-28
- Acceptance date:
- 2025-11-14
- DOI:
- EISSN:
-
2397-3374
- ISSN:
-
2397-3374
- Language:
-
English
- Keywords:
- Pubs id:
-
2352479
- Local pid:
-
pubs:2352479
- Deposit date:
-
2025-12-19
- ARK identifier:
Terms of use
- Copyright holder:
- Luppi et al.
- Copyright date:
- 2026
- Rights statement:
- © The Author(s) 2026.Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record