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PPARγ co-activator-1α (PGC-1α) reduces amyloid-β generation through a PPARγ-dependent mechanism

Abstract:

We have previously reported that the nuclear receptor peroxisome proliferator activated receptor-γ (PPARγ) regulates the transcription of β-secretase (BACE1), a key enzyme involved in amyloid-β (Aβ) generation. Here, we aimed to investigate the role of PPARγ coactivator-1α (PGC-1α), which controls major metabolic functions through the co-activation of PPARγ and other transcription factors. Western blotting experiments with nuclear extracts from brain cortex of AD cases and controls showed a r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3233/JAD-2011-101356

Authors


More by this author
Department:
Oxford, MSD, NDM, Target Discovery Institute
Bogdanovic, N More by this author
Alzheimers Research UK More from this funder
Publisher:
IOS Press Publisher's website
Journal:
Journal of Alzheimer's Disease Journal website
Volume:
25
Issue:
1
Pages:
151-162
Publication date:
2011
Acceptance date:
2011-02-02
DOI:
ISSN:
1875-8908 and 1387-2877
Pubs id:
pubs:614445
URN:
uri:49722d62-1e44-448f-a792-1e7dc7890970
UUID:
uuid:49722d62-1e44-448f-a792-1e7dc7890970
Local pid:
pubs:614445

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