Journal article : Review
The emerging circardian phenotype of borderline personality disorder: Mechanisms, opportunities and future directions
- Abstract:
-
Purpose of Review
We review the recent evidence suggesting that circadian rhythm disturbance is a common unaddressed feature of borderline personality disorder (BPD); amelioration of which may confer substantial clinical benefit. We assess chronobiological BPD studies from a mechanistic and translational perspective and highlight opportunities for the future development of this hypothesis.
Recent Findings The emerging circadian phenotype of BPD is characterised by a preponderance of comorbid circadian rhythm sleep-wake disorders, phase delayed and misaligned rest-activity patterns and attenuated amplitudes of usually well-characterised circadian rhythms. Such disturbances may exacerbate symptom severity, and specific maladaptive personality dimensions may produce a liability towards extremes in chronotype. Pilot studies suggest intervention may be beneficial, but development is limited.
Summary Endogenous and exogenous circadian rhythm disturbances appear to be common in BPD. The interface between psychiatry and chronobiology has led previously to novel efficacious strategies for the treatment of psychiatric disorders. We believe that better characterisation of the circadian phenotype in BPD will lead to a directed biological target for treatment in a condition where there is a regrettable paucity of accessible therapies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, 513.1KB, Terms of use)
-
- Publisher copy:
- 10.1007/s11920-021-01236-w
Authors
- Publisher:
- Springer
- Journal:
- Current Psychiatry Reports More from this journal
- Volume:
- 23
- Issue:
- 5
- Article number:
- 30
- Publication date:
- 2021-04-09
- Acceptance date:
- 2021-02-23
- DOI:
- EISSN:
-
1535-1645
- ISSN:
-
1523-3812
- Pmid:
-
33835306
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1173137
- Local pid:
-
pubs:1173137
- Deposit date:
-
2022-04-08
Terms of use
- Copyright holder:
- McGowan and Saunders
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record