Journal article
The Dantu blood group prevents parasite growth in vivo: evidence from a controlled human malaria infection study
- Abstract:
-
Background:
The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen, which is associated with 74% protection against severe and complicated P. falciparum malaria infections in homozygous individuals, similar to that provided by the sickle haemoglobin allele (HbS). Recent in vitro studies sug... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 807.1KB, Terms of use)
-
- Publisher copy:
- 10.7554/elife.83874
Authors
- Publisher:
- eLife
- Journal:
- eLife More from this journal
- Volume:
- 12
- Article number:
- e83874
- Place of publication:
- England
- Publication date:
- 2023-06-13
- Acceptance date:
- 2023-05-11
- DOI:
- EISSN:
-
2050-084X
- Pmid:
-
37310872
- Language:
-
English
- Keywords:
- Pubs id:
-
1462503
- Local pid:
-
pubs:1462503
- Deposit date:
-
2024-02-21
- ARK identifier:
Terms of use
- Copyright holder:
- Kariuki et al
- Copyright date:
- 2023
- Rights statement:
- © 2023 Kariuki et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record